putrinolab.bsky.social

@putrinolab.bsky.social [ View ] Oct 24, 2023 at 14:07 UTC

that other approaches exist and have validity, so we’re respectful of differing opinions (and ask for the same grace). One thing you can count on is that we won't stop looking for new, better and actionable solutions for people living with infection-associated complex chronic illnesses /end

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@putrinolab.bsky.social [ View ] Oct 24, 2023 at 14:04 UTC

pathogen is eventually eliminated. That is why understanding how people with #LongCOVID, #Lyme and #MECFS biologically differ from healthy controls is a research priority for us. Once again - this is *our* approach and thought process as we tackle these challenging issues. We are aware 16/

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@putrinolab.bsky.social [ View ] Oct 24, 2023 at 14:03 UTC

(various antiviral therapies). We believe both to be important because while cures are the goal, people need treatments that can move the needle NOW, and we also must acknowledge that persistent pathogens cause damage that may need to be fixed even if the persistent 15/

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@putrinolab.bsky.social [ View ] Oct 24, 2023 at 14:02 UTC

on understanding the underlying pathophysiology of #LongCOVID and other infection-associated complex chronic illness. We have multiple clinical trials in the works that focus on symptom management (such as use of enzymes, antihistamines and nerve stimulation) and addressing persistent pathogens 14/

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@putrinolab.bsky.social [ View ] Oct 24, 2023 at 14:01 UTC

who respond to low-dose ativan because it is a mast cell stabilizer NOT because it is treating anxiety. Mechanisms matter and fitting these pieces of the puzzle are crucial for making sure less people are being minimized and gaslit as they attempt different treatments. Our team is highly focused 13/

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@putrinolab.bsky.social [ View ] Oct 24, 2023 at 14:00 UTC

Similarly it is important to highlight physiological reasons WHY these people may be experiencing benefit because for too long this benefit has been framed as treating depression and contributes to
ongoing gaslighting. The same can be said of folks with #LongCOVID, #MECFS and #Lyme 12/

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@putrinolab.bsky.social [ View ] Oct 24, 2023 at 14:00 UTC

findings were interesting because it explains why some with LongCOVID experience benefit from low dose SSRIs. I know that not ALL people experience benefit (some people have worsening symptoms, but we must not ignore those who experience benefit just because it doesn't fit everyone's narrative. 11/

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@putrinolab.bsky.social [ View ] Oct 24, 2023 at 13:58 UTC

an appropriate treatment for the low cortisol that we saw in the MY-LC cohort we published in Nature earlier this month. Similarly, my team IS NOT is saying that based on the results of this weeks Cell paper that all folks with LongCOVID should take prozac. I DID mention that the serotonin 10/

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@putrinolab.bsky.social [ View ] Oct 24, 2023 at 13:57 UTC

materials will ALWAYS present a more nuanced interpretation. You will not see serious authors of this sort of work saying "we've done it: this is THE biomarker", because that it NOT what our research shows. We also won't say that cortisol is a TREATMENT for #LongCOVID or even 9/

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@putrinolab.bsky.social [ View ] Oct 24, 2023 at 13:56 UTC

We strongly acknowledge that due to the complexity of infection-associated chronic illness not all people with LongCOVID will show these differences. When media reports on this work, they often want to overstate the importance of the work so that it fits into a nice press-release, but the source 8/

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@putrinolab.bsky.social [ View ] Oct 24, 2023 at 13:56 UTC

pathogens. Hence our excitement about our own recent study in people with LongCOVID that we completed with the wonderful Prof Iwasaki and other work like that completed by Prof Levy and co-authors this week. These studies highlight biological differences between people with LC and health controls 7/

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@putrinolab.bsky.social [ View ] Oct 24, 2023 at 13:55 UTC

a non-zero chance of causing malignancy(~0.16%): which sounds small until 60M ppl get tested...either way, we are all in when it comes to new techniques for identifying persistent pathogens but also IN PARALLEL (not in isolation) we see the value in understanding the effect on physiology of these 6/

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@putrinolab.bsky.social [ View ] Oct 24, 2023 at 13:54 UTC

There is technology on the horizon being developed for radioligands that bind to spike and can be used in conjunction with PET scanning to search the whole body for viral persistence. I think that this is a very promising direction, but I'm also mindful of the fact that PET scans carry with them 5/

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@putrinolab.bsky.social [ View ] Oct 24, 2023 at 13:53 UTC

of persistent virus in their gut, only around 30% have circulating spike proteins in their blood, many tissues that may harbor persistent SARS-CoV-2 can only reasonably be accessed post-mortem, so what I'm saying is that at this time testing for persistent virus, though we still try, is shaky. 4/

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@putrinolab.bsky.social [ View ] Oct 24, 2023 at 13:52 UTC

world who has been consistently and relentlessly leading and facilitating great research in this space. Part of understanding how to detect AND treat persistent pathogens in the body is to understand persisting pathogen itself. Not everyone with #LongCOVID has easily measurable evidence 3/

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@putrinolab.bsky.social [ View ] Oct 24, 2023 at 13:50 UTC

practice. We are approaching our new center through the lens of establishing novel ways of treating chronic, persisting pathogens and the damage that they cause. This is why our scientific strategy is being led by the incredible Amy Proal, because IMO there is no one better in the 2/

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@putrinolab.bsky.social [ View ] Oct 24, 2023 at 13:49 UTC

As we continue to learn more each day about LongCOVID and other infection-associated chronic illnesses like chronic Lyme and ME/CFS, I want to once again transparently share our team's approach, thought process and philosophy for interpreting science and translating it into common clinical 1/

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@putrinolab.bsky.social [ View ] Oct 24, 2023 at 13:45 UTC

Filed under “more stuff I should have read she’s ago”, thank you so much, @julierehmeyer for sending me this and for all you do in general for the conversation around #LongCovid, #MECFS, chronic #lyme and all infection- (AND *exposure-*) associated complex chronic illnesses

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@putrinolab.bsky.social [ View ] Oct 16, 2023 at 16:05 UTC

This research is another nail in the coffin of BPS minimizers of #LongCOVID, another step toward more nuanced understandings of how persistent pathogens can influence every organ system, and another step toward actionable treatments for people with LongCOVID.

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@putrinolab.bsky.social [ View ] Oct 16, 2023 at 16:04 UTC

IMO this work drives an important mechanistic understanding for why a portion people with #LongCOVID are responding to treatments like low-dose SSRIs and psychedelics despite not having depression or other psychological diagnoses and how viral persistence can drive these changes.

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@putrinolab.bsky.social [ View ] Oct 16, 2023 at 16:03 UTC

Fantastic new #longcovid research out today from a phenomenal interdisciplinary team showing more biological differences in a cross-species study. Congrats to Maayan Levy, Ben Abramoff and many other incredible scientists on this beautiful work.

www.statnews.com/2023/10/16/l...

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@putrinolab.bsky.social [ View ] Oct 10, 2023 at 20:49 UTC

🥰

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@putrinolab.bsky.social [ View ] Oct 10, 2023 at 20:48 UTC

A reminder about #longcovidkids: they won’t present to you like #LongCovid adults, which is why cases are being wildly underreported with shaky science. Our kids deserve better. Thanks Mary Van Beusekom for covering this important topic. www.cidrap.umn.edu/covid-19/not...

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@putrinolab.bsky.social [ View ] Oct 10, 2023 at 20:45 UTC

Excited to be in this new space to talk and learn about #longcovid! 👋🏼🙏🏻

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