Sean Carroll's avatar

Sean Carroll

@seanmcarroll.bsky.social

So for strands longer than 181 base pairs, there is not enough time or matter in the universe to search through all the possibilities. And the human genome has 3 billion. So the search that Nature has actually done is very sparse indeed.

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Sean Matthews's avatar Sean Matthews @seanmatthews1.bsky.social
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You know, stochastic gradient descent is a very effective general optimisation algorithm.

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Bilal Kerman's avatar Bilal Kerman @bilalkerman.bsky.social
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But the selection perfection doesn't need to be in the whole genome at once. Each gene can be optimized at different organisms or in the same organism simultaneously.

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Sean Carroll's avatar Sean Carroll @seanmcarroll.bsky.social
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Nothing very profound to conclude, just some thoughts I scribbled down for a great workshop on the philosophy of thermodynamics organized by @wmyrvold.bsky.social this week.

It would be great to better understand how Nature actually does search through the space of complex systems!

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Fredbo's avatar Fredbo @fredbo.bsky.social
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Not that I subscribe to the idea, but is this in any way supportive of a teleological theory of our existence?

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