I’ll do a thread on here, probably on the bad place too
And: yeah, masks and respirators are a stop gap. The sustainable solutions to indoor air are engineering solutions…on which your institution could lead.
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This…I don’t know why there’s an expectation that mucosal vaccines will be a magic bullet when the immunity from prior infection isn’t all that durable.
Also, FluMist was pulled from the market for being less effective than IM; it’s back with a tweak, but still not clearly superior.
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The local house finches* have also figured out that I have peanuts; they can’t outcompete the crows for them or open the shells themselves, but they’re eager for the scraps the crows leave behind. @carlbergstrom.com
*or something. Too amateur to tell vs a couple of other possibilities
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I agree, but I also don’t think there’s any convincing evidence it *doesn’t* help. Is there any study that is
- prospective and randomized
- has a clinical definition of “Long Covid” (not a yes/no questionnaire of poorly defined symptoms)
- sufficiently powered to detect an OR of 0.9 or so
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Reposted by Dirk KS
The queen is back! Hello again, Seattle Reign FC!
www.sounderatheart.com/2024/01/seat...
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There’s a comic for that, by Jens von Bergmann github.com/mountainMath...
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The opening paragraph of every Covid paper is damn near identical, or at least was in 2020/2021. Novel coronavirus first found in Wuhan spread around the world etc etc. Yes, usually with five citations or more in the single paragraph. Still tiring, but not plagiarism.
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I thought I heard one in the Arboretum a few weeks ago! I didn’t see it, and I’ve never seen one though I live nearby, and I thought maybe I was mistaken. But they’re pretty distinctive, so maybe I did.
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Seriously? No one planned for throwback uniform day, much less a team sale?
If we lost the best logo ever to these jokers I will be so mad.
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Oh darn, they’ll have to use a crest they already have the trademark for…
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DIY PAPR Buggy: www.researchgate.net/publication/...
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rosemarymosco.com/comics/bird-...
Though if they’re in your backyard, size alone should tell you. Ravens are BIG birds. Crows are pigeon-length but not as round.
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RATs have consistently shown > 95% sensitivity at detecting viral loads at a PCR Ct < 25 throughout the pandemic. Usage guidance needs to remind people that early symptoms may occur at lower viral loads. Which is why serial testing has been recommended, though clarity could be improved.
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Why do we make policy as if there will be no effect on transmission? Clearly the effect is smaller than we’d wish but even a 20% reduction of R from universal up-to-date vaccination would pull the peak — and the number of over 65s in hospital — down quite a bit
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Paper discussing earlier symptoms compare to peak viral load: academic.oup.com/cid/advance-...
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Preprint date November 29, 2023, study period Oct 2021 to March 2022, they separate Delta vs Omicron in their analysis.
Sensitivity by Ct value:
≤ 25: 95%
25-30: 19%
≥ 30: 2%
www.medrxiv.org/content/10.1...
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As far as to contagiousness: multiple studies have compared RATs to positive viral culture. Which is not a perfect proxy for contagiousness, but what study design do you propose — that could pass an IRB — to measure more directly?
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No one study has specifically compared multiple variants - these are all studies of virus in the wild. But time-of-study-period is a proxy for variant, and results across time have been consistent. Give me a moment and I’ll pull references.
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Are you contagious at that instant, with symptoms but negative RAT? Hard to know for sure, but the big reason you should still stay home is that the rise in viral load can be very rapid. Could easily have a positive RAT three hours later.
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No. No study that has compared RATs to PCR Ct results has ever found the RATs to be less sensitive to newer variants. What studies *have* found though is that symptoms start now at higher Ct (lower load), not as a result of variant per se but as a result of increased prior immunity.
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And of course “contagious” isn’t a binary state. Some people put out a lot more virus than others.
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But RAT positives do correlate with high viral load (low qPCR Ct) and successful viral culture, so bright line — yes, absolutely contagious, no question. The questions are at the margins — is a faint line at the tail end of infection still contagious? Are you definitely in the clear after one neg?
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