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Tatiana Dimitriu@tatianadimitriu.bsky.social |
249 followers 238 following 22 posts
@royalsociety University Research Fellow in St Andrews. Bacterial evolution, mobile genetic elements & defence systems, antibiotic resistance, social interactions. 🇫🇷 with some 🇷🇴 and 🇺🇦 roots. She/her
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Rachel M. Wheatley
@rwheatley8.bsky.social
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Please share: competitively funded PhD open to international students. Working on multi-drug resistant bacterial pathogens, microbiomes, and infection models 🦠 at Queen’s University Belfast with myself, Miguel Valvano & Rebecca Ingram:
www.findaphd.com/phds/project...
0 replies 14 reposts 7 likes
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Tatiana Dimitriu
@tatianadimitriu.bsky.social
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I was stress-eating Sainsbury's "camembert", now I'm eating more, in celebration ☺️
0 replies 0 reposts 7 likes
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Tatiana Dimitriu
@tatianadimitriu.bsky.social
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City girl younger me would not have predicted it, but my best therapy from the world going wrong is looking at the cute teenage cows happily snoozing in the fields on the way to work. Makes my day every time.
0 replies 0 reposts 2 likes
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Rachel M. Wheatley
@rwheatley8.bsky.social
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Out today in Evolution Letters 🎉🎉
📄 Antibiotic resistance alters the ability of Pseudomonas aeruginosa to invade bacteria from the respiratory microbiome 📄
academic.oup.com/evlett/advan...
0 replies 8 reposts 13 likes
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Tatiana Dimitriu
@tatianadimitriu.bsky.social
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merci Anne!
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Anne Chevallereau
@annechevallereau.bsky.social
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Really nice (and necessary!) study about the role of RM systems in shaping conjugative plasmid propagation. Congrats Tatiana et al. !
1 replies 1 reposts 2 likes
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Tatiana Dimitriu
@tatianadimitriu.bsky.social
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A voté! Thanks to the French system for giving me the option of voting either online or in Edinburgh. And hope the knot in my stomach about these elections won't get worse over the next weeks (1st time since I arrived in the UK in 2015 that I feel this much worse about French than UK vote).
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Tatiana Dimitriu
@tatianadimitriu.bsky.social
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That does not mean RM has no role in shaping plasmid dynamics and gene flow! Even a few fold difference can have large consequences in a mixed population; and the fact that plasmids fight against RM is itself evidence that they have been under selection by these defence systems.
0 replies 0 reposts 1 likes
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Tatiana Dimitriu
@tatianadimitriu.bsky.social
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Overall the median effect of RM on conjugation was only ~14-fold (and even that is based on short-term conjugation assays - the plasmids which have escaped restriction are then free to spread in the recipient population).
1 replies 0 reposts 1 likes
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Tatiana Dimitriu
@tatianadimitriu.bsky.social
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And finally, the Type III systems we tested had little efficiency across plasmids, suggesting they are not very good at targeting conjugation in general, independently of specific anti-restriction functions.
1 replies 0 reposts 1 likes
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Tatiana Dimitriu
@tatianadimitriu.bsky.social
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The number of recognition sites per plasmid had a large effect, especially for Type II RM systems (the ones we get restriction enzymes from). For Type I systems, susceptibility to restriction seems to depend mostly on the carriage of anti-restriction genes.
1 replies 0 reposts 1 likes
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Tatiana Dimitriu
@tatianadimitriu.bsky.social
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We asked how efficient RM systems are against plasmid conjugation in E. coli. We found a lot of variation depending on RM system and plasmid combination, but on average, restriction was not very strong! For a rough summary of the patterns we observed (but see the preprint for more):
1 replies 0 reposts 2 likes
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Tatiana Dimitriu
@tatianadimitriu.bsky.social
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New preprint on the interactions between conjugative plasmids and defence systems (restriction-modification systems), with Mark Szczelkun and Edze Westra #MicroSky
www.biorxiv.org/content/10.1...
2 replies 10 reposts 25 likes
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Olaya Rendueles
@olayarendueles.bsky.social
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#JobAlert
Interested in a #Postdoc in microbial genetics ?
DM for more details
Join me in #Toulouse, a vibrant dynamic city ☀️ offering high quality of life & near 🏔️ &🏖️
Applications until end of month.
** Please RT ! **
#ASMicrobe #Klebsiella #MicroSky
0 replies 12 reposts 3 likes
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Alan McNally
@alanmcn1.bsky.social
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The ridiculously talented @nwheeler443.bsky.social is looking for a bioinformatics PDRF here in Birmingham
www.jobs.ac.uk/job/DIB267/r...
0 replies 15 reposts 9 likes
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Zamin Iqbal
@zaminiqbal.bsky.social
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First paper from my student Daria Frolova's PhD now on biorxiv:
www.biorxiv.org/content/10.1...
The key question: plasmids change structurally ~as fast as they mutate, so how can we decide whether 2 plasmids are "the same plasmid" for epi purposes?
1/n
1 replies 20 reposts 23 likes
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Alex Crits-Christoph
@acritschristoph.bsky.social
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Going viral: The role of mobile genetic elements in bacterial immunity
www.cell.com/cell-host-mi...
0 replies 19 reposts 16 likes
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Tatiana Dimitriu
@tatianadimitriu.bsky.social
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Hard to focus on science these days. Last night I had a nightmare about the far right being elected in France. Now I'm laughing at the (slightly less extreme) right, for which it seems who is the boss (and decides to ally with the far right or not) is determined by who got the keys to the office.
1 replies 0 reposts 3 likes
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Marjon de Vos
@lizscurious.bsky.social
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New preprint from the lab:
Microbial interactions affect the tempo and mode of antibiotic resistance evolution. www.biorxiv.org/content/10.1...
#microsky
1 replies 20 reposts 18 likes
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Tatiana Dimitriu
@tatianadimitriu.bsky.social
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The Brancuși exhibition in Centre Pompidou combined many many things close to my heart
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Tatiana Dimitriu
@tatianadimitriu.bsky.social
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I'm recruiting a Research Technician to work on plasmid transmission and antimicrobial resistance in St Andrews, to start in October. Deadline for applications is 19 June. Please share!
www.vacancies.st-andrews.ac.uk/Vacancies/W/...
0 replies 23 reposts 14 likes
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Alex Crits-Christoph
@acritschristoph.bsky.social
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Cool to observe conjugation and recombination of chimeric BGCs between strains in the laboratory:
0 replies 3 reposts 8 likes
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Rachel M. Wheatley
@rwheatley8.bsky.social
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Please share: Funded PhD project on the ecology and evolution of antibiotic resistance 🦠🧬🫁 at Queen’s University Belfast.
Application deadline: 21 June
Please 📧 me with any questions, happy to chat!
www.findaphd.com/phds/project...
0 replies 30 reposts 16 likes
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Anna Dewar
@annadewar.bsky.social
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Why do pangenomes vary so much across bacteria? 🦠🧬
We show that bacterial lifestyle is the key factor shaping variation in pangenome fluidity.
Read more in our paper out now in PNAS:
doi.org/10.1073/pnas...
With Chunhui Hao @lauriebelch.bsky.social Melanie Ghoul @stuwest.bsky.social
1 replies 16 reposts 24 likes
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Fabienne Benz
@fabbenz.bsky.social
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Sharing our latest paper as my first post here 🔵 💙
Plasmids encode Type IV CRISPR-Cas to fight other plasmids💥⚔️
Now out in Cell Host & Microbe www.sciencedirect.com/science/arti...
2 replies 12 reposts 19 likes
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Daniel Padfield
@padpadpadpad.bsky.social
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Accepted in MBE: we do targeted sequencing of Myxococotta across environments to try understand how transitions between biomes happen through macroevolutionary time. TL;DR Evolved generalism mediated transitions between specialists in different biomes. academic.oup.com/mbe/advance-...
4 replies 9 reposts 7 likes
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Chris Mancuso
@mancusosci.bsky.social
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Why don’t people who live together have the same strains of microbes? Tami Lieberman (@contaminatedsci.bsky.social) and I put forward one underexplored reason in our new preprint:
Intraspecies warfare restricts strain coexistence in human skin microbiomes
4 replies 27 reposts 32 likes
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Sean Meaden
@seanmeaden.bsky.social
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I've got a fully funded, 4-year PhD position available to work on virus-bacteria interactions in soils. Part of the GenerationResearch scheme at York aimed at widening access to postgrad research. Please share!
generationresearch.ac.uk/phd_proposal...
0 replies 37 reposts 23 likes
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Michael Brockhurst
@brockhurstlab.bsky.social
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Does resistance evolve within patients? Yeah, but it’s complicated, evidence is piecemeal, and we need to make far better use of clinical trials for quantitative understanding of how & why AMR outcomes vary between patients. Led by @matthewjshepherd.bsky.social
www.nature.com/articles/s41...
3 replies 20 reposts 27 likes
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Steve Diggle
@digglelab.bsky.social
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Our new proof of principle paper showing how cooperative behaviors can be exploited to drive antibiotic sensitivity into infections www.microbiologyresearch.org/content/jour...
0 replies 7 reposts 6 likes
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Jorge Moura de Sousa
@jmouradesousa.bsky.social
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New paper from the lab, the mysteries involving the genetic elements that move by being mobilized by other MGEs. Hitcher Genetic Elements are distinctive, ancient and diverse.
ecoevorxiv.org/repository/v...
1 replies 10 reposts 9 likes
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Ellinor Alseth
@ellinoralseth.bsky.social
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Our paper on "The impact of phage and phage resistance on microbial community dynamics" is finally out in PLOS Biology! What a journey it's been to get here, and I couldn't have done it without my fab co-authors journals.plos.org/plosbiology/...
1 replies 20 reposts 34 likes
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Tatiana Dimitriu
@tatianadimitriu.bsky.social
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working to make friends with these two little ones
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Rafael Peña-Miller
@penamiller.bsky.social
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Our paper on plasmid-driven heterogeneity is finally out!
www.nature.com/articles/s41...
@sanmillan.bsky.social @ayari.bsky.social @jerorb.bsky.social @craigmaclean.bsky.social
1 replies 8 reposts 15 likes
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Alex Crits-Christoph
@acritschristoph.bsky.social
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Beautiful work - isolation of a crassphage, and turns out it is a phage-plasmid!
1 replies 24 reposts 38 likes
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Willem van Schaik
@wvschaik.bsky.social
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Excellent paper by Dan Andersson's group
'Bacteria can compensate the fitness costs of amplified resistance genes via a bypass mechanism'
www.nature.com/articles/s41...
0 replies 13 reposts 29 likes
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Olaya Rendueles
@olayarendueles.bsky.social
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Our latest work is finally out!
How #capsule serotypes of #Klebsiella pneumoniae influences #phage adsorption and infection, and #plasmid conjugation efficiency.
Plasmids care about size-phages dont!
Great work led by Matthieu Haudiquet in the lab @epcrocha.bsky.social
doi.org/10.1038/s414...
1 replies 28 reposts 33 likes
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João Botelho
@joaoftsbotelho.bsky.social
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New preprint alert!
Ever wondered about the relationship status between defense systems and HGT? Well... it's complicated! Dive into our study where we dissect this intricate bond across thousands of microbial genomes! #Genomics #Microbiology
www.biorxiv.org/content/10.1...
2 replies 16 reposts 31 likes
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Alvaro San Millan
@sanmillan.bsky.social
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New preprint in collaboration with @asantoslopez.bsky.social lab and led by Jorge Sastre. Combining experimental evolution and analyses of longitudinal samples from hospitalised patients, we unveiled a new mechanism of plasmid-mediated evolution beyond HGT 1/8
www.biorxiv.org/content/10.1...
12 replies 28 reposts 44 likes
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Tatiana Dimitriu
@tatianadimitriu.bsky.social
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I seem to be at that stage of living in the UK where I just had to google translate "restart" to french to help my mum with her phone.
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Sciences
@sciences.skyfleet.blue
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A cryptic plasmid is among the most numerous genetic elements in the human gut
1 replies 11 reposts 15 likes
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Alvaro San Millan
@sanmillan.bsky.social
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New perspective paper with the amazing @asanchezlab.bsky.social @javierdelafuente.bsky.social and Juan Diaz-Colunga.
Can we use global epistasis patterns to predict/understand plasmid-mediated AMR evolution? www.embopress.org/doi/full/10....
0 replies 16 reposts 25 likes
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Alex Crits-Christoph
@acritschristoph.bsky.social
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Really like this paper from @fnobrega.bsky.social and co - some defense systems statistically co-occur with each other across genomes and correspondingly show synergistic effects in vitro
Bacterial defense systems exhibit synergistic anti-phage activity
www.sciencedirect.com/science/arti...
1 replies 12 reposts 24 likes
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Will Matlock
@wtmatlock.bsky.social
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It was a pleasure to collaborate with Sam on this massive BSI-associated plasmid surveillance study: www.nature.com/articles/s41...
1 replies 8 reposts 10 likes
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Eduardo Rocha
@epcrocha.bsky.social
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Our latest on phage-plasmids(PP) is out! Two main findings. PP recombine more with (other) plasmids and phages than the latter, thereby connecting them. PP can become just phages or plasmids, which may then transition to be conjugative. All the world’s an MGE! www.nature.com/articles/s41...
0 replies 33 reposts 30 likes
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Alan McNally
@alanmcn1.bsky.social
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Our latest paper is out. The brainchild of @drrebeccajhall.bsky.social We had shown how different E. coli strains respond to the same MDR plasmid. Here we show how one strain responds to different MDR plasmids
journals.asm.org/doi/10.1128/...
0 replies 17 reposts 37 likes
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Paul Hoskisson 🧫 🦠🐸
@paulhoskisson.bsky.social
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This is very cool from Dave Grainger et al…
H-NS is a bacterial transposon capture protein www.biorxiv.org/content/10.1...
2 replies 13 reposts 17 likes
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Paul Hoskisson 🧫 🦠🐸
@paulhoskisson.bsky.social
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This is a very cool piece of work from Jenna Gallie et al - Large-scale duplication events underpin population-level flexibility in tRNA gene copy number in Pseudomonas fluorescens academic.oup.com/nar/advance-...
0 replies 5 reposts 10 likes
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GruberLab
@gruberlab.bsky.social
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Our new work on the Wadjet (JET) anti-plasmid defence system is out:
authors.elsevier.com/a/1iXM53vVUP...
Showing structures of SMC complexes on extruded DNA (first time?)
and blockage (!) of DNA extrusion by obstacles on DNA
and more...
0 replies 11 reposts 13 likes
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Paul Hoskisson 🧫 🦠🐸
@paulhoskisson.bsky.social
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This is fascinating and yet more evidence that suggests we shouldn’t dismiss the effects of synonymous mutations! Synonymous edits in the Escherichia coli genome have substantial and condition-dependent effects on fitness www.pnas.org/doi/10.1073/...
1 replies 11 reposts 15 likes